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psma positive cell line lncap  (ATCC)


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    Structured Review

    ATCC psma positive cell line lncap
    Retention of [ 89 Zr]Zr-A11 and [ 89 Zr]Zr-A12 in PSMA + <t>LNCAP</t> tumors (●; black symbol and line) and PSMA − PC-3 tumors ( ● ; red symbol and line). Tumor-bearing mice ( n = 4 or 5 per group) were injected with either [ 89 Zr]Zr-A12 or [ 89 Zr]Zr-A11 via the tail vein. When comparing the radioactivity retention at 1 h, 4 h and 24 h, animals receiving [ 89 Zr]Zr-A12 had significantly more radioactivity associated with PSMA + tumors than PSMA − tumors at 1h ( p = 0.002), 4h ( p = 0.004) and 24h ( p = 0.003). Contrarily, when comparing the radioactivity retention at 1 h, 4 h and 24 h for animals receiving [ 89 Zr]Zr-A11, the retention of radioactivity in PSMA + and PSMA − tumors was non-significant at 1 h ( p = 0.6), 4 h ( p = 0.8) and 24 h ( p = 0.3).
    Psma Positive Cell Line Lncap, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 2671 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/psma+positive+cell+line+lncap/LNCaP+clone+FGC/pmc12899641-184-1-15
    Average 99 stars, based on 2671 article reviews
    psma positive cell line lncap - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "Preclinical Evaluation of a Radiolabeled Anti-PSMA Dimeric Aptamer in a Murine Model of Human Prostate Cancer"

    Article Title: Preclinical Evaluation of a Radiolabeled Anti-PSMA Dimeric Aptamer in a Murine Model of Human Prostate Cancer

    Journal: Molecules

    doi: 10.3390/molecules31030493

    Retention of [ 89 Zr]Zr-A11 and [ 89 Zr]Zr-A12 in PSMA + LNCAP tumors (●; black symbol and line) and PSMA − PC-3 tumors ( ● ; red symbol and line). Tumor-bearing mice ( n = 4 or 5 per group) were injected with either [ 89 Zr]Zr-A12 or [ 89 Zr]Zr-A11 via the tail vein. When comparing the radioactivity retention at 1 h, 4 h and 24 h, animals receiving [ 89 Zr]Zr-A12 had significantly more radioactivity associated with PSMA + tumors than PSMA − tumors at 1h ( p = 0.002), 4h ( p = 0.004) and 24h ( p = 0.003). Contrarily, when comparing the radioactivity retention at 1 h, 4 h and 24 h for animals receiving [ 89 Zr]Zr-A11, the retention of radioactivity in PSMA + and PSMA − tumors was non-significant at 1 h ( p = 0.6), 4 h ( p = 0.8) and 24 h ( p = 0.3).
    Figure Legend Snippet: Retention of [ 89 Zr]Zr-A11 and [ 89 Zr]Zr-A12 in PSMA + LNCAP tumors (●; black symbol and line) and PSMA − PC-3 tumors ( ● ; red symbol and line). Tumor-bearing mice ( n = 4 or 5 per group) were injected with either [ 89 Zr]Zr-A12 or [ 89 Zr]Zr-A11 via the tail vein. When comparing the radioactivity retention at 1 h, 4 h and 24 h, animals receiving [ 89 Zr]Zr-A12 had significantly more radioactivity associated with PSMA + tumors than PSMA − tumors at 1h ( p = 0.002), 4h ( p = 0.004) and 24h ( p = 0.003). Contrarily, when comparing the radioactivity retention at 1 h, 4 h and 24 h for animals receiving [ 89 Zr]Zr-A11, the retention of radioactivity in PSMA + and PSMA − tumors was non-significant at 1 h ( p = 0.6), 4 h ( p = 0.8) and 24 h ( p = 0.3).

    Techniques Used: Injection, Radioactivity

    Related Articles

    Injection:

    Article Title: Preclinical Evaluation of a Radiolabeled Anti-PSMA Dimeric Aptamer in a Murine Model of Human Prostate Cancer
    Article Snippet: The poly-L-lysine-coated Corning BioCoat coverslips were obtained from ThermoFisher Scientific, Inc.The poly-L-lysine-coated Corning BioCoat coverslips were obtained from ThermoFisher Scientific, Inc.. The PSMA-positive cell line LNCaP (CRL-1740) and PSMA-negative cell line PC-3 (CRL-1435) were procured from ATCC (Manassas, VA, USA).. The Cy3-labeled DAC (A4), Cy5-labeled DAC (A5), Cy3-labeled dA16 oligo (A7) and the Cy5-labeled dT16 oligo (A8) were purchased from Aptagen, LLC (Jacobus, PA, USA) with a purity of greater than 95%.The Cy3-labeled DAC (A4), Cy5-labeled DAC (A5), Cy3-labeled dA16 oligo (A7) and the Cy5-labeled dT16 oligo (A8) were purchased from Aptagen, LLC (Jacobus, PA, USA) with a purity of greater than 95%.

    Radioactivity:

    Article Title: Preclinical Evaluation of a Radiolabeled Anti-PSMA Dimeric Aptamer in a Murine Model of Human Prostate Cancer
    Article Snippet: The poly-L-lysine-coated Corning BioCoat coverslips were obtained from ThermoFisher Scientific, Inc.The poly-L-lysine-coated Corning BioCoat coverslips were obtained from ThermoFisher Scientific, Inc.. The PSMA-positive cell line LNCaP (CRL-1740) and PSMA-negative cell line PC-3 (CRL-1435) were procured from ATCC (Manassas, VA, USA).. The Cy3-labeled DAC (A4), Cy5-labeled DAC (A5), Cy3-labeled dA16 oligo (A7) and the Cy5-labeled dT16 oligo (A8) were purchased from Aptagen, LLC (Jacobus, PA, USA) with a purity of greater than 95%.The Cy3-labeled DAC (A4), Cy5-labeled DAC (A5), Cy3-labeled dA16 oligo (A7) and the Cy5-labeled dT16 oligo (A8) were purchased from Aptagen, LLC (Jacobus, PA, USA) with a purity of greater than 95%.



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    Retention of [ 89 Zr]Zr-A11 and [ 89 Zr]Zr-A12 in PSMA + <t>LNCAP</t> tumors (●; black symbol and line) and PSMA − PC-3 tumors ( ● ; red symbol and line). Tumor-bearing mice ( n = 4 or 5 per group) were injected with either [ 89 Zr]Zr-A12 or [ 89 Zr]Zr-A11 via the tail vein. When comparing the radioactivity retention at 1 h, 4 h and 24 h, animals receiving [ 89 Zr]Zr-A12 had significantly more radioactivity associated with PSMA + tumors than PSMA − tumors at 1h ( p = 0.002), 4h ( p = 0.004) and 24h ( p = 0.003). Contrarily, when comparing the radioactivity retention at 1 h, 4 h and 24 h for animals receiving [ 89 Zr]Zr-A11, the retention of radioactivity in PSMA + and PSMA − tumors was non-significant at 1 h ( p = 0.6), 4 h ( p = 0.8) and 24 h ( p = 0.3).
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    Image Search Results


    Retention of [ 89 Zr]Zr-A11 and [ 89 Zr]Zr-A12 in PSMA + LNCAP tumors (●; black symbol and line) and PSMA − PC-3 tumors ( ● ; red symbol and line). Tumor-bearing mice ( n = 4 or 5 per group) were injected with either [ 89 Zr]Zr-A12 or [ 89 Zr]Zr-A11 via the tail vein. When comparing the radioactivity retention at 1 h, 4 h and 24 h, animals receiving [ 89 Zr]Zr-A12 had significantly more radioactivity associated with PSMA + tumors than PSMA − tumors at 1h ( p = 0.002), 4h ( p = 0.004) and 24h ( p = 0.003). Contrarily, when comparing the radioactivity retention at 1 h, 4 h and 24 h for animals receiving [ 89 Zr]Zr-A11, the retention of radioactivity in PSMA + and PSMA − tumors was non-significant at 1 h ( p = 0.6), 4 h ( p = 0.8) and 24 h ( p = 0.3).

    Journal: Molecules

    Article Title: Preclinical Evaluation of a Radiolabeled Anti-PSMA Dimeric Aptamer in a Murine Model of Human Prostate Cancer

    doi: 10.3390/molecules31030493

    Figure Lengend Snippet: Retention of [ 89 Zr]Zr-A11 and [ 89 Zr]Zr-A12 in PSMA + LNCAP tumors (●; black symbol and line) and PSMA − PC-3 tumors ( ● ; red symbol and line). Tumor-bearing mice ( n = 4 or 5 per group) were injected with either [ 89 Zr]Zr-A12 or [ 89 Zr]Zr-A11 via the tail vein. When comparing the radioactivity retention at 1 h, 4 h and 24 h, animals receiving [ 89 Zr]Zr-A12 had significantly more radioactivity associated with PSMA + tumors than PSMA − tumors at 1h ( p = 0.002), 4h ( p = 0.004) and 24h ( p = 0.003). Contrarily, when comparing the radioactivity retention at 1 h, 4 h and 24 h for animals receiving [ 89 Zr]Zr-A11, the retention of radioactivity in PSMA + and PSMA − tumors was non-significant at 1 h ( p = 0.6), 4 h ( p = 0.8) and 24 h ( p = 0.3).

    Article Snippet: The PSMA-positive cell line LNCaP (CRL-1740) and PSMA-negative cell line PC-3 (CRL-1435) were procured from ATCC (Manassas, VA, USA).

    Techniques: Injection, Radioactivity

    Widefield fluorescence microscopy images of PC3-PIP, LNCaP and PC3 flu cells after incubation with Cy5-conjugates 8 , 9 and 10 (2.5 μ m or 10 μ m , 37 °C, 2 h) with or without blocking (100-fold excess 2-PMPA). Nuclei were stained with DAPI (cyan). The Cy5 signal is shown in magenta. λ exc (DAPI) = 395 nm; λ exc (Cy5) = 640 nm. Scale bar = 50 μm.

    Journal: Journal of Medicinal Chemistry

    Article Title: Zwitterionic Modification of PSMA Ligands Reduces Off-Target Binding and Tissue Retention

    doi: 10.1021/acs.jmedchem.5c03849

    Figure Lengend Snippet: Widefield fluorescence microscopy images of PC3-PIP, LNCaP and PC3 flu cells after incubation with Cy5-conjugates 8 , 9 and 10 (2.5 μ m or 10 μ m , 37 °C, 2 h) with or without blocking (100-fold excess 2-PMPA). Nuclei were stained with DAPI (cyan). The Cy5 signal is shown in magenta. λ exc (DAPI) = 395 nm; λ exc (Cy5) = 640 nm. Scale bar = 50 μm.

    Article Snippet: The PSMA-positive cell line LNCaP was obtained from DSMZ (Deutsche Sammlung von Mikroorganismen and Zelllinien #ACC 256).

    Techniques: Fluorescence, Microscopy, Incubation, Blocking Assay, Staining

    Representative confocal microscopy images of (A) PC3-PIP and LNCaP cells after incubation with Cy5 conjugates 8 , 9 and 10 (10 μ m , 2 h, 37 °C) and (B) ZW800−617 13 (10 μ m , 2 h, 37 °C). Nuclei were stained with DAPI (cyan). The Cy5 signal is shown in magenta and the ZW800 signal in yellow. Images are shown as maximum intensity projections of z-stacks acquired with a 63x oil immersion objective. λ exc (DAPI) = 405 nm; λ exc (Cy5) = 653 nm, λ exc (ZW800) = 770 nm. Scale bar = 20 μm.

    Journal: Journal of Medicinal Chemistry

    Article Title: Zwitterionic Modification of PSMA Ligands Reduces Off-Target Binding and Tissue Retention

    doi: 10.1021/acs.jmedchem.5c03849

    Figure Lengend Snippet: Representative confocal microscopy images of (A) PC3-PIP and LNCaP cells after incubation with Cy5 conjugates 8 , 9 and 10 (10 μ m , 2 h, 37 °C) and (B) ZW800−617 13 (10 μ m , 2 h, 37 °C). Nuclei were stained with DAPI (cyan). The Cy5 signal is shown in magenta and the ZW800 signal in yellow. Images are shown as maximum intensity projections of z-stacks acquired with a 63x oil immersion objective. λ exc (DAPI) = 405 nm; λ exc (Cy5) = 653 nm, λ exc (ZW800) = 770 nm. Scale bar = 20 μm.

    Article Snippet: The PSMA-positive cell line LNCaP was obtained from DSMZ (Deutsche Sammlung von Mikroorganismen and Zelllinien #ACC 256).

    Techniques: Confocal Microscopy, Incubation, Staining

    Full body cryo-fluorescence tomography images (maximum intensity projection) of PC3-PIP and PC3 flu tumor-bearing xenograft mice obtained 4 h p.i. of 20 nmol dose of Cy5 conjugates 8 , 9 , 10 and ZW800 conjugate 13 . Selected organs are marked with the following abbreviations: PC3-PIP = PSMA-positive tumor xenograft; PC3 flu = PSMA-negative tumor xenograft; LG = lacrimal glands; Bl = bladder; GI = gastrointestinal tract, K i = kidney. Images were captured at 45 μm/pixel resolution with the following set ups: Cy5 channel = 640 nm excitation laser and 680/13 nm emission filter; ZW800 channel = 780 nm excitation laser and 840/70 nm emission filter.

    Journal: Journal of Medicinal Chemistry

    Article Title: Zwitterionic Modification of PSMA Ligands Reduces Off-Target Binding and Tissue Retention

    doi: 10.1021/acs.jmedchem.5c03849

    Figure Lengend Snippet: Full body cryo-fluorescence tomography images (maximum intensity projection) of PC3-PIP and PC3 flu tumor-bearing xenograft mice obtained 4 h p.i. of 20 nmol dose of Cy5 conjugates 8 , 9 , 10 and ZW800 conjugate 13 . Selected organs are marked with the following abbreviations: PC3-PIP = PSMA-positive tumor xenograft; PC3 flu = PSMA-negative tumor xenograft; LG = lacrimal glands; Bl = bladder; GI = gastrointestinal tract, K i = kidney. Images were captured at 45 μm/pixel resolution with the following set ups: Cy5 channel = 640 nm excitation laser and 680/13 nm emission filter; ZW800 channel = 780 nm excitation laser and 840/70 nm emission filter.

    Article Snippet: The PSMA-positive cell line LNCaP was obtained from DSMZ (Deutsche Sammlung von Mikroorganismen and Zelllinien #ACC 256).

    Techniques: Fluorescence, Tomography